Interaction between endothelin and vasodilators in the human internal mammary artery.
نویسندگان
چکیده
منابع مشابه
Beta-adrenoceptor-mediated responsiveness of human internal mammary artery
The internal mammary artery (IMA) is currently the preferred conduit for myocardial revascularization. However, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. The mechanism of spasm has not been clearly defined. Since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...
متن کاملbeta-adrenoceptor-mediated responsiveness of human internal mammary artery
the internal mammary artery (ima) is currently the preferred conduit for myocardial revascularization. however, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. the mechanism of spasm has not been clearly defined. since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...
متن کاملReactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting.
OBJECTIVE The internal thoracic artery (ITA) is a useful conduit for coronary artery bypass grafting (CABG) and the patency rate is indispensable. Recently we have developed a method for increasing ITA blood flow during surgery by directly injecting phosphodiesterase III inhibitor (PDE III-I) into the left ITA (LITA) to prevent its contracture. In this study, we compared the reactivity of LITA ...
متن کاملEffects of two new dihydropyridine derivatives, mepudipine and dibudipine, on isolated human internal mammary artery and rat left atrium
Among the present classes of calcium channel blockers, dihydropyridine derivatives are widely used in the therapy of hypertension, angina pectoris and the other cardiovascular diseases. Since the prototype of dihydropyridine derivatives, nifedipine, does not have the optimum pharmacokinetic and pharmacodynamic characteristics, several attempts have been made to synthesize other drugs in this ...
متن کاملThe in vitro effects of iloprost with other vasodilators on the human internal thoracic artery.
PURPOSE We aimed (a) to analyze the effects of iloprost as a vasodilator on the human internal thoracic artery (ITA) and (b) to compare these effects with the effects of other vasodilators now being used in the clinic. METHODS Following transfer into only Krebs solution or into Krebs solution containing papaverine or iloprost, human ITA strips were then incubated only in Krebs or in Krebs wit...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1994
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1994.tb04391.x